Journal: Journal of Medical Virology
Article Title: Multicenter Evaluation of the QIAstat‐Dx and the BioFire Multiplex Panel Tests for the Detection of Respiratory Pathogens
doi: 10.1002/jmv.70129
Figure Lengend Snippet: Respiratory pathogen detection by BioFire‐RP2.1 and QIAstat‐Dx‐RP2.0 multiplex panel tests. (A) Detection of respiratory pathogens in 269 respiratory samples from 259 patients using BioFire‐RP2.1 (orange) and QIAstat‐Dx‐RP2.0 (blue) between November 2023 and February 2024. (B) Age distribution of patients who tested positive for the respective respiratory pathogens (median, 25% and 75%). (C) Respiratory pathogen loads in patient samples that tested positive with both the BioFire‐RP2.1 and QIAstat‐Dx‐RP2.0 (yellow), or were detected exclusively in one of the multiplex panel tests (red; median, 25% and 75%). p values of the Mann‐Whitney U ‐test, with a single asterisk (*) indicating a significance level of less than 0.05, a double asterisk (**) indicating a significance level of less than 0.01, and a triple asterisk (***) indicating a significance level of less than 0.001. HAdV, adenovirus (HAdV); HBoV, human bocavirus; HCoV, human coronavirus (types ‐229E, ‐HKU1, ‐NL63 and ‐OC43); hMPV, human metapneumovirus A and B; HPIV, human parainfluenzavirus; HRV/HEV, human rhino‐/enterovirus; IV‐A, influenzavirus A; IV‐B, influenzavirus B; M. pneu, Mycoplasma pneumoniae ; MERS, Middle East respiratory syndrome coronavirus; RSV, respiratory syncytial virus A and B (RSV); SCoV2/SARS‐CoV‐2, severe respiratory syndrome coronavirus.
Article Snippet: Among those are the BioFire respiratory multiplex panel version 2.1 (BioFire‐RP2.1) and the QIAstat‐Dx respiratory panel version 2.0 (QIAstat‐Dx‐RP2.0), generating results from 23 different respiratory targets, including SARS‐CoV‐2 in approximately 1 h. In this prospective multicenter study, we conducted a comparative evaluation of the BioFire‐RP2.1 and QIAstat‐Dx‐RP2.0 multiplex panel tests using 269 respiratory clinical specimens, prospectively collected from patients with RTIs.
Techniques: Multiplex Assay, MANN-WHITNEY, Virus